The path to Parkinson’s disease: All roads lead to the nigrosome

The main neuropathological feature of Parkinson’s disease is the loss of dopaminergic neurons in the substantia nigra pars compacta. Specifically, dopaminergic neurons in the ventral tier of the substantia nigra pars compacta, also known as the nigrosome, are notably affected in Parkinson’s disease, whereas those in the dorsal tier and ventral tegmental area demonstrate a much lower degree of degeneration.

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