Team finds new potential causes of rare and lethal bone cancer

Little is known about the genetics and biology of chordoma, a rare and aggressive bone tumor. Chordomas occur in approximately one in a million people in the U.S. a year and 5% of these are in children. These tumors can arise anywhere along the spine in adults. However, in children, these tumors occur mostly at the base of the skull, making complete surgical removal challenging or impossible. Any tumor remnants are treated with high doses of radiation—which can cause significant damage to the developing brain.

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