Study reveals circadian clock can be leveraged to enhance cancer immunotherapy

A multidisciplinary research team at the University of California, Irvine has revealed that the circadian clock—the biological pacemaker that governs daily rhythms in physiological processes, including immune functions—can be leveraged to enhance the efficacy of checkpoint inhibitor cancer therapy. Checkpoint inhibitors block different proteins from binding to tumor cells, allowing the immune system’s T cells to kill the tumor.

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