New therapeutic approach for frontotemporal dementia uses modified viruses to replace a missing protein in the brain

Frontotemporal dementia is a currently incurable brain disease causing memory loss, speech disorders, and changes in personality. In 5–12% of cases, a decline in progranulin triggers the disease. The loss of this protein leads to deficiencies in protein breakdown, resulting in the deposition of insoluble toxic proteins. This leads to inflammation of the brain, neuronal death, and associated massive functional disorders of the central nervous system.

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