A research team led by Professor Haruhisa Inoue (Department of Cell Growth and Differentiation) derived iPS cells (iPSC) from α-synucleinopathy patients with early-onset familial Parkinson’s disease (PD) carrying the α-synuclein (SNCA) A53T mutation and differentiated them into cerebral cortical neurons in an attempt to decipher the underlying molecular mechanisms involved in neurodegeneration to develop new therapies for the devastating disease.
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